中文名 | CD38 inhibitor |
英文名 | CD38 inhibitor 78c |
别名 | 化合物CD38 INHIBITOR 1 4-((反式-4-(2-甲氧基乙氧基)环己基)氨基)-1-甲基-6-(噻唑-5-基)喹啉-2(1H)-酮 |
英文别名 | cd38-1 CD38 inhibitor CD38 inhibitor 1 CD38 inhibitor 78c CD38 inhibitor 1 (compound 78c) 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone 4-((trans-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one 2(1H)-Quinolinone, 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)- |
CAS | 1700637-55-3 |
化学式 | C22H27N3O3S |
分子量 | 413.536 |
溶解度 | 溶于DMSO |
存储条件 | -20℃ |
靶点 | IC50: 7.3 nM (hCD38), 1.9 nM (mouse CD38) Ki: 0.3 nM (WT hCD38) |
参考资料 展开查看 | 1: Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, JeuneMR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG,Shearer TW, Shewchuk LM, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC.Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitorsof NAD-Hydrolyzing Enzyme CD38. J Med Chem. 2015 Sep 10;58(17):7021-56. doi:10.1021/acs.jmedchem.5b00992. Epub 2015 Aug 24. PubMed PMID: 26267483. 2: Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, RudM, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL,Passos JF, Doles JD, Becherer DJ, Chini EN. A Potent and Specific CD38 InhibitorAmeliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline.Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.PubMed PMID: 29719225; PubMed Central PMCID: PMC5935140. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.418 ml | 12.091 ml | 24.182 ml |
5 mM | 0.484 ml | 2.418 ml | 4.836 ml |
10 mM | 0.242 ml | 1.209 ml | 2.418 ml |
5 mM | 0.048 ml | 0.242 ml | 0.484 ml |
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